Drug interactions
Deflazacort + Parecoxib
Severity: Moderate
Deflazacort and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, a COX-2 selective NSAID prodrug of valdecoxib, taken with a corticosteroid can increase the likelihood of gastrointestinal ulceration and bleeding. COX-2 selectivity reduces but does not remove this risk, especially in older patients or those with prior ulcers.
What this interaction means in plain words
Deflazacort and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from corticosteroid effects and prostaglandin inhibition by the NSAID.
What to do
Use the shortest possible course of parecoxib, and consider a proton pump inhibitor in patients at higher GI risk. Watch for dyspepsia, melena and other signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Parecoxib?
MediHelp rates the interaction as moderate. Deflazacort and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, a COX-2 selective NSAID prodrug of valdecoxib, taken with a corticosteroid can increase the likelihood of gastrointestinal ulceration and bleeding. COX-2 selectivity reduces but does not remove this risk, especially in older patients or those with prior ulcers.
How serious is the interaction between Deflazacort and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest possible course of parecoxib, and consider a proton pump inhibitor in patients at higher GI risk. Watch for dyspepsia, melena and other signs of GI bleeding.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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