Drug interactions
Deflazacort + Penicillin g aqueous
Severity: Minor
Deflazacort and Penicillin g aqueous: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aqueous penicillin G given in high doses, as sodium or potassium salt, can cause urinary potassium wasting and hypokalemia. Deflazacort also promotes potassium excretion, so the effects may add together.
What this interaction means in plain words
Deflazacort and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive renal potassium loss from the corticosteroid's mineralocorticoid activity and the poorly reabsorbed penicillin anion.
What to do
Check serum potassium periodically during high-dose penicillin G therapy with a corticosteroid and replace potassium if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Penicillin g aqueous?
MediHelp rates the interaction as minor. Deflazacort and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aqueous penicillin G given in high doses, as sodium or potassium salt, can cause urinary potassium wasting and hypokalemia. Deflazacort also promotes potassium excretion, so the effects may add together.
How serious is the interaction between Deflazacort and Penicillin g aqueous?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium periodically during high-dose penicillin G therapy with a corticosteroid and replace potassium if low.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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