Drug interactions
Deflazacort + Phenindione
Severity: Moderate
Deflazacort and Phenindione: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can unpredictably change the response to oral anticoagulants, either lowering or raising the INR. They may also increase bleeding risk through gastric mucosal injury and effects on vascular fragility.
What this interaction means in plain words
Deflazacort and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not firmly established; it likely involves variable effects on coagulation and a pharmacodynamic increase in bleeding risk.
What to do
Monitor INR more often when deflazacort is started, changed or stopped, and adjust the phenindione dose accordingly. Watch for gastrointestinal bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Phenindione?
MediHelp rates the interaction as moderate. Deflazacort and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can unpredictably change the response to oral anticoagulants, either lowering or raising the INR. They may also increase bleeding risk through gastric mucosal injury and effects on vascular fragility.
How serious is the interaction between Deflazacort and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more often when deflazacort is started, changed or stopped, and adjust the phenindione dose accordingly. Watch for gastrointestinal bleeding.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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