Drug interactions
Deflazacort + Pneumococcal vaccine heptavalent
Severity: Moderate
Deflazacort and Pneumococcal vaccine heptavalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort may blunt the response to the inactivated pneumococcal conjugate vaccine. Patients on steroids are at higher risk of pneumococcal disease, so the vaccine remains important.
What this interaction means in plain words
Deflazacort and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression reduces antibody production after vaccination.
What to do
Vaccinate according to schedule, ideally before starting prolonged steroids. Follow current guidance on subsequent doses for immunocompromised patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Pneumococcal vaccine heptavalent?
MediHelp rates the interaction as moderate. Deflazacort and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort may blunt the response to the inactivated pneumococcal conjugate vaccine. Patients on steroids are at higher risk of pneumococcal disease, so the vaccine remains important.
How serious is the interaction between Deflazacort and Pneumococcal vaccine heptavalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to schedule, ideally before starting prolonged steroids. Follow current guidance on subsequent doses for immunocompromised patients.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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