Drug interactions
Deflazacort + Pneumococcal vaccine polyvalent
Severity: Moderate
Deflazacort and Pneumococcal vaccine polyvalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can reduce antibody responses to polysaccharide pneumococcal vaccine. Patients on steroids are at higher risk of pneumococcal infection, so vaccination remains valuable.
What this interaction means in plain words
Deflazacort and Pneumococcal vaccine polyvalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression decreases antibody production following vaccination.
What to do
Vaccinate per schedule, preferably before long-term steroids. Follow local guidance on revaccination for immunocompromised patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Pneumococcal vaccine polyvalent?
MediHelp rates the interaction as moderate. Deflazacort and Pneumococcal vaccine polyvalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can reduce antibody responses to polysaccharide pneumococcal vaccine. Patients on steroids are at higher risk of pneumococcal infection, so vaccination remains valuable.
How serious is the interaction between Deflazacort and Pneumococcal vaccine polyvalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate per schedule, preferably before long-term steroids. Follow local guidance on revaccination for immunocompromised patients.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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