Drug interactions
Deflazacort + Polyethylene glycol and electrolytes
Severity: Moderate
Deflazacort and Polyethylene glycol and electrolytes: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid and electrolyte losses, and corticosteroids add renal potassium loss. Together they may lead to hypokalemia and dehydration.
What this interaction means in plain words
Deflazacort and Polyethylene glycol and electrolytes can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium depletion from gastrointestinal losses and corticosteroid-induced renal potassium excretion.
What to do
Ensure adequate hydration and check electrolytes before and after bowel preparation in patients on chronic corticosteroids, particularly those with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Polyethylene glycol and electrolytes?
MediHelp rates the interaction as moderate. Deflazacort and Polyethylene glycol and electrolytes can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid and electrolyte losses, and corticosteroids add renal potassium loss. Together they may lead to hypokalemia and dehydration.
How serious is the interaction between Deflazacort and Polyethylene glycol and electrolytes?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check electrolytes before and after bowel preparation in patients on chronic corticosteroids, particularly those with cardiac disease.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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