Drug interactions
Deflazacort + Rabies vaccine chick embryo cell derived
Severity: Major
Deflazacort and Rabies vaccine chick embryo cell derived: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort may reduce the antibody response to this inactivated rabies vaccine, which matters because rabies is almost invariably fatal. The vaccine cannot cause infection.
What this interaction means in plain words
Deflazacort and Rabies vaccine chick embryo cell derived can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Glucocorticoid immunosuppression decreases rabies neutralizing antibody production.
What to do
Do not delay post-exposure prophylaxis; give with rabies immunoglobulin as indicated and measure neutralizing antibody titres afterward. Complete pre-exposure series before steroids where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Rabies vaccine chick embryo cell derived?
MediHelp rates the interaction as major. Deflazacort and Rabies vaccine chick embryo cell derived can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deflazacort may reduce the antibody response to this inactivated rabies vaccine, which matters because rabies is almost invariably fatal. The vaccine cannot cause infection.
How serious is the interaction between Deflazacort and Rabies vaccine chick embryo cell derived?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not delay post-exposure prophylaxis; give with rabies immunoglobulin as indicated and measure neutralizing antibody titres afterward. Complete pre-exposure series before steroids where feasible.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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