Drug interactions
Deflazacort + Rotavirus oral vaccine live
Severity: Major
Deflazacort and Rotavirus oral vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live attenuated rotavirus may replicate more extensively in immunosuppressed patients on deflazacort, and the immune response may be reduced. This is mainly relevant to infants exposed to maternal steroids or those on steroids themselves.
What this interaction means in plain words
Deflazacort and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Glucocorticoid immunosuppression impairs control of live attenuated virus and vaccine immunogenicity.
What to do
Avoid in infants receiving immunosuppressive corticosteroid doses; follow labeling for deferral. Low-dose or short-course steroids may not require deferral per local guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Rotavirus oral vaccine live?
MediHelp rates the interaction as major. Deflazacort and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live attenuated rotavirus may replicate more extensively in immunosuppressed patients on deflazacort, and the immune response may be reduced. This is mainly relevant to infants exposed to maternal steroids or those on steroids themselves.
How serious is the interaction between Deflazacort and Rotavirus oral vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in infants receiving immunosuppressive corticosteroid doses; follow labeling for deferral. Low-dose or short-course steroids may not require deferral per local guidance.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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