Drug interactions
Deflazacort + Rubella vaccine
Severity: Contraindicated
Deflazacort and Rubella vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rubella vaccine contains live attenuated virus that may replicate excessively in patients immunosuppressed by deflazacort. The immune response may also be reduced.
What this interaction means in plain words
Deflazacort and Rubella vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Glucocorticoid immunosuppression impairs control of live attenuated virus and reduces vaccine immunogenicity.
What to do
Avoid at immunosuppressive doses; vaccinate before starting steroids or after the labeled washout. Check rubella immunity and defer until steroid therapy is reduced or stopped.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Rubella vaccine?
MediHelp rates the interaction as contraindicated. Deflazacort and Rubella vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rubella vaccine contains live attenuated virus that may replicate excessively in patients immunosuppressed by deflazacort. The immune response may also be reduced.
How serious is the interaction between Deflazacort and Rubella vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid at immunosuppressive doses; vaccinate before starting steroids or after the labeled washout. Check rubella immunity and defer until steroid therapy is reduced or stopped.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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