Drug interactions
Deflazacort + Salicylates
Severity: Moderate
Deflazacort and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates combined with a corticosteroid raise the risk of gastric irritation, ulceration and bleeding. Corticosteroids can also lower salicylate levels, and levels may rise when the steroid is withdrawn.
What this interaction means in plain words
Deflazacort and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury, with possible corticosteroid-induced increase in salicylate clearance.
What to do
Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for GI bleeding. Reassess salicylate response if deflazacort is stopped or its dose is changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Salicylates?
MediHelp rates the interaction as moderate. Deflazacort and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates combined with a corticosteroid raise the risk of gastric irritation, ulceration and bleeding. Corticosteroids can also lower salicylate levels, and levels may rise when the steroid is withdrawn.
How serious is the interaction between Deflazacort and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for GI bleeding. Reassess salicylate response if deflazacort is stopped or its dose is changed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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