Drug interactions
Deflazacort + Salsalate
Severity: Moderate
Deflazacort and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate prodrug, and taking it with a corticosteroid can raise the risk of gastric ulceration and bleeding, though salsalate is often considered less irritating to the stomach than aspirin. Corticosteroids may also lower salicylate levels.
What this interaction means in plain words
Deflazacort and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury, with possible corticosteroid-induced increase in salicylate clearance.
What to do
Consider a proton pump inhibitor in patients with GI risk factors and monitor for GI bleeding. Check the salicylate response when deflazacort is stopped or its dose is altered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Salsalate?
MediHelp rates the interaction as moderate. Deflazacort and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate prodrug, and taking it with a corticosteroid can raise the risk of gastric ulceration and bleeding, though salsalate is often considered less irritating to the stomach than aspirin. Corticosteroids may also lower salicylate levels.
How serious is the interaction between Deflazacort and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in patients with GI risk factors and monitor for GI bleeding. Check the salicylate response when deflazacort is stopped or its dose is altered.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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