Drug interactions
Deflazacort + Smallpox vaccine live
Severity: Contraindicated
Deflazacort and Smallpox vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live vaccinia can spread progressively in immunosuppressed patients, causing severe vaccinia complications. Deflazacort also reduces the vaccine response.
What this interaction means in plain words
Deflazacort and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Glucocorticoid immunosuppression impairs control of replicating vaccinia virus and blunts immunity.
What to do
Avoid in patients on immunosuppressive doses of deflazacort; consider the non-replicating vaccine alternative if available. Defer until steroid therapy has ended for the labeled interval unless risk of exposure outweighs harm.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Deflazacort and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia can spread progressively in immunosuppressed patients, causing severe vaccinia complications. Deflazacort also reduces the vaccine response.
How serious is the interaction between Deflazacort and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients on immunosuppressive doses of deflazacort; consider the non-replicating vaccine alternative if available. Defer until steroid therapy has ended for the labeled interval unless risk of exposure outweighs harm.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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