Drug interactions
Deflazacort + Sodium bicarbonate
Severity: Minor
Deflazacort and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium bicarbonate can drive potassium into cells and cause metabolic alkalosis, which promotes renal potassium loss. Together with a corticosteroid, this can add to hypokalemia, mostly with large or repeated doses.
What this interaction means in plain words
Deflazacort and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Additive lowering of serum potassium via alkalosis-related intracellular shift and corticosteroid-induced renal excretion.
What to do
Monitor serum potassium when high doses of bicarbonate are given with a corticosteroid and replace potassium as required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Deflazacort with Sodium bicarbonate?
MediHelp rates the interaction as minor. Deflazacort and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium bicarbonate can drive potassium into cells and cause metabolic alkalosis, which promotes renal potassium loss. Together with a corticosteroid, this can add to hypokalemia, mostly with large or repeated doses.
How serious is the interaction between Deflazacort and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when high doses of bicarbonate are given with a corticosteroid and replace potassium as required.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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