Drug interactions
Deflazacort + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Deflazacort and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This bowel preparation causes diarrhea with fluid and electrolyte loss, which may include hypokalemia and hyponatremia. Deflazacort adds renal potassium loss, increasing the chance of significant electrolyte disturbance.
What this interaction means in plain words
Deflazacort and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium depletion from gastrointestinal losses and corticosteroid-induced renal potassium excretion.
What to do
Encourage adequate fluid intake and check electrolytes in at-risk patients, such as those with cardiac or renal disease, before and after the preparation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Deflazacort and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This bowel preparation causes diarrhea with fluid and electrolyte loss, which may include hypokalemia and hyponatremia. Deflazacort adds renal potassium loss, increasing the chance of significant electrolyte disturbance.
How serious is the interaction between Deflazacort and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Encourage adequate fluid intake and check electrolytes in at-risk patients, such as those with cardiac or renal disease, before and after the preparation.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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