Drug interactions
Deflazacort + Somatrem
Severity: Moderate
Deflazacort and Somatrem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucocorticoids given at supraphysiologic doses can reduce the growth-promoting effects of growth hormone, which matters in children. Growth hormone can also alter cortisol activation and unmask adrenal insufficiency in treated patients.
What this interaction means in plain words
Deflazacort and Somatrem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of growth hormone by glucocorticoids and growth hormone inhibition of 11-beta-HSD1.
What to do
Track growth velocity and use the lowest effective deflazacort dose. Review glucocorticoid replacement needs after growth hormone is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Somatrem?
MediHelp rates the interaction as moderate. Deflazacort and Somatrem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids given at supraphysiologic doses can reduce the growth-promoting effects of growth hormone, which matters in children. Growth hormone can also alter cortisol activation and unmask adrenal insufficiency in treated patients.
How serious is the interaction between Deflazacort and Somatrem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Track growth velocity and use the lowest effective deflazacort dose. Review glucocorticoid replacement needs after growth hormone is started.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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