Drug interactions
Deflazacort + Somatropin
Severity: Moderate
Deflazacort and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic glucocorticoid therapy such as deflazacort can blunt the growth-promoting effects of somatropin. This matters in children with growth impairment, and growth hormone may also alter cortisol activation.
What this interaction means in plain words
Deflazacort and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Somatropin belongs to Endocrine.
Why it happens
Glucocorticoids antagonize growth hormone action, and growth hormone inhibits 11-beta-HSD-1.
What to do
Keep the deflazacort dose at the lowest effective level and monitor growth velocity. Adjust somatropin dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Somatropin?
MediHelp rates the interaction as moderate. Deflazacort and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chronic glucocorticoid therapy such as deflazacort can blunt the growth-promoting effects of somatropin. This matters in children with growth impairment, and growth hormone may also alter cortisol activation.
How serious is the interaction between Deflazacort and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the deflazacort dose at the lowest effective level and monitor growth velocity. Adjust somatropin dose according to response.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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