Drug interactions
Deflazacort + Squill
Severity: Moderate
Deflazacort and Squill: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides, and corticosteroids can cause hypokalemia. Low potassium increases the risk of glycoside-related arrhythmias.
What this interaction means in plain words
Deflazacort and Squill can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-induced potassium loss sensitizes the myocardium to cardiac glycoside toxicity.
What to do
Monitor serum potassium and magnesium and correct deficits. Watch for arrhythmia or signs of glycoside toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Squill?
MediHelp rates the interaction as moderate. Deflazacort and Squill can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Squill contains cardiac glycosides, and corticosteroids can cause hypokalemia. Low potassium increases the risk of glycoside-related arrhythmias.
How serious is the interaction between Deflazacort and Squill?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits. Watch for arrhythmia or signs of glycoside toxicity.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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