Drug interactions
Deflazacort + Telmisartan-amlodipine
Severity: Moderate
Deflazacort and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a corticosteroid that can cause potassium loss, sodium and fluid retention, and may raise blood pressure. This can counteract the antihypertensive effect of telmisartan-amlodipine. Potassium effects are partly offset by telmisartan.
What this interaction means in plain words
Deflazacort and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Corticosteroid mineralocorticoid activity promotes sodium retention and potassium excretion, opposing the blood pressure lowering action.
What to do
Monitor blood pressure, fluid status and serum potassium during long-term deflazacort use. Adjust antihypertensive therapy if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Deflazacort and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a corticosteroid that can cause potassium loss, sodium and fluid retention, and may raise blood pressure. This can counteract the antihypertensive effect of telmisartan-amlodipine. Potassium effects are partly offset by telmisartan.
How serious is the interaction between Deflazacort and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium during long-term deflazacort use. Adjust antihypertensive therapy if blood pressure rises.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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