Drug interactions
Deflazacort + Tetanus toxoid adsorbed or fluid
Severity: Moderate
Deflazacort and Tetanus toxoid adsorbed or fluid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort may reduce the antibody response to tetanus toxoid, leaving protection lower than expected. The toxoid is non-live and carries no infection risk.
What this interaction means in plain words
Deflazacort and Tetanus toxoid adsorbed or fluid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression reduces antitoxin antibody production.
What to do
Give the toxoid when indicated, including for wound management, and do not delay it. Consider tetanus immunoglobulin for high-risk wounds and a booster after steroids are stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as moderate. Deflazacort and Tetanus toxoid adsorbed or fluid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort may reduce the antibody response to tetanus toxoid, leaving protection lower than expected. The toxoid is non-live and carries no infection risk.
How serious is the interaction between Deflazacort and Tetanus toxoid adsorbed or fluid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the toxoid when indicated, including for wound management, and do not delay it. Consider tetanus immunoglobulin for high-risk wounds and a booster after steroids are stopped.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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