Drug interactions
Deflazacort + Typhoid polysaccharide vaccine
Severity: Minor
Deflazacort and Typhoid polysaccharide vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids such as deflazacort can reduce the antibody response to the inactivated typhoid polysaccharide vaccine. This vaccine is non-live, so it carries no risk of vaccine-related infection and can be given if needed.
What this interaction means in plain words
Deflazacort and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid-induced immunosuppression may blunt the vaccine-induced immune response.
What to do
Administer the vaccine at least 2 weeks before starting deflazacort when possible; otherwise vaccinate and counsel that protection may be incomplete, with attention to food and water precautions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deflazacort and Typhoid polysaccharide vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as minor. Deflazacort and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids such as deflazacort can reduce the antibody response to the inactivated typhoid polysaccharide vaccine. This vaccine is non-live, so it carries no risk of vaccine-related infection and can be given if needed.
How serious is the interaction between Deflazacort and Typhoid polysaccharide vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer the vaccine at least 2 weeks before starting deflazacort when possible; otherwise vaccinate and counsel that protection may be incomplete, with attention to food and water precautions.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
