Drug interactions
Deflazacort + Zoster vaccine recombinant
Severity: Minor
Deflazacort and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroid immunosuppression may blunt the immune response to the recombinant zoster vaccine, reducing protection. The vaccine is non-live, so it is not contraindicated and can be given to patients on steroids.
What this interaction means in plain words
Deflazacort and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid-mediated suppression of lymphocyte function reduces vaccine immunogenicity.
What to do
Vaccinate when clinically indicated, ideally when steroid dose is lowest if therapy can be timed. Do not delay vaccination in patients who need ongoing steroids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Deflazacort and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroid immunosuppression may blunt the immune response to the recombinant zoster vaccine, reducing protection. The vaccine is non-live, so it is not contraindicated and can be given to patients on steroids.
How serious is the interaction between Deflazacort and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when clinically indicated, ideally when steroid dose is lowest if therapy can be timed. Do not delay vaccination in patients who need ongoing steroids.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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