Drug interactions
Degarelix + Escitalopram
Severity: Moderate
Degarelix and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and escitalopram has a dose-related QT effect. Combining them may add to the risk of ventricular arrhythmia.
What this interaction means in plain words
Degarelix and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Escitalopram belongs to Central Nervous System.
Why it happens
Additive QT prolongation from degarelix-induced androgen deprivation and escitalopram.
What to do
Assess baseline ECG and electrolytes and monitor periodically. Keep the escitalopram dose low and consider an alternative if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Escitalopram?
MediHelp rates the interaction as moderate. Degarelix and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and escitalopram has a dose-related QT effect. Combining them may add to the risk of ventricular arrhythmia.
How serious is the interaction between Degarelix and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess baseline ECG and electrolytes and monitor periodically. Keep the escitalopram dose low and consider an alternative if the QTc lengthens.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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