Drug interactions
Cisapride + Degarelix
Severity: Major
Cisapride and Degarelix: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix may prolong the QT interval. Combined with cisapride, the risk of ventricular arrhythmia is raised.
What this interaction means in plain words
Cisapride and Degarelix can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisapride belongs to Gastrointestinal Tract; Degarelix belongs to Endocrine.
Why it happens
Additive QT prolongation; degarelix effect is attributed to androgen deprivation altering cardiac repolarization.
What to do
Avoid cisapride where possible and use an alternative GI prokinetic. If both are required, obtain a baseline ECG and monitor the QTc and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisapride and Degarelix, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Degarelix + Dronedarone Major
Frequently asked questions
Can I take Cisapride with Degarelix?
MediHelp rates the interaction as major. Cisapride and Degarelix can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Androgen deprivation therapy with degarelix may prolong the QT interval. Combined with cisapride, the risk of ventricular arrhythmia is raised.
How serious is the interaction between Cisapride and Degarelix?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cisapride where possible and use an alternative GI prokinetic. If both are required, obtain a baseline ECG and monitor the QTc and electrolytes.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
