Drug interactions
Degarelix + Lithium
Severity: Moderate
Degarelix and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and lithium has also been linked to QT changes and conduction abnormalities. The combination may increase arrhythmia risk, particularly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Degarelix and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Evaluate baseline ECG and electrolytes and monitor QTc during therapy. Avoid adding other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Lithium?
MediHelp rates the interaction as moderate. Degarelix and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and lithium has also been linked to QT changes and conduction abnormalities. The combination may increase arrhythmia risk, particularly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Degarelix and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Evaluate baseline ECG and electrolytes and monitor QTc during therapy. Avoid adding other QT-prolonging drugs where possible.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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