Drug interactions
Degarelix + Octreotide
Severity: Moderate
Degarelix and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and octreotide has been associated with QT changes and bradycardia. Combined use may increase the risk of arrhythmia.
What this interaction means in plain words
Degarelix and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check baseline ECG and electrolytes and repeat ECG during treatment, especially with other risk factors. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Octreotide?
MediHelp rates the interaction as moderate. Degarelix and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and octreotide has been associated with QT changes and bradycardia. Combined use may increase the risk of arrhythmia.
How serious is the interaction between Degarelix and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and repeat ECG during treatment, especially with other risk factors. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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