Drug interactions
Degarelix + Venlafaxine
Severity: Moderate
Degarelix and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can prolong the QT interval, and venlafaxine may add a small QT effect. The combination may modestly increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Degarelix and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization while venlafaxine has a weak effect on cardiac ion channels.
What to do
Obtain a baseline ECG and monitor the QTc, especially with other QT-prolonging drugs or electrolyte abnormalities. Correct potassium and magnesium disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Venlafaxine?
MediHelp rates the interaction as moderate. Degarelix and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as degarelix can prolong the QT interval, and venlafaxine may add a small QT effect. The combination may modestly increase arrhythmia risk in susceptible patients.
How serious is the interaction between Degarelix and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc, especially with other QT-prolonging drugs or electrolyte abnormalities. Correct potassium and magnesium disturbances.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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