Drug interactions
Demeclocycline + Tretinoin
Severity: Moderate
Demeclocycline and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tretinoin and demeclocycline can cause photosensitivity, and demeclocycline is a particularly strong photosensitizer. Together they may cause more severe phototoxic skin reactions. Tetracyclines combined with retinoids also raise the risk of intracranial hypertension.
What this interaction means in plain words
Demeclocycline and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive phototoxicity, and a possible additive risk of raised intracranial pressure.
What to do
Counsel strict sun protection and consider an alternative to the tetracycline. Evaluate promptly any persistent headache or visual disturbance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Demeclocycline with Tretinoin?
MediHelp rates the interaction as moderate. Demeclocycline and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both tretinoin and demeclocycline can cause photosensitivity, and demeclocycline is a particularly strong photosensitizer. Together they may cause more severe phototoxic skin reactions. Tetracyclines combined with retinoids also raise the risk of intracranial hypertension.
How serious is the interaction between Demeclocycline and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict sun protection and consider an alternative to the tetracycline. Evaluate promptly any persistent headache or visual disturbance.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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