Drug interactions
Omadacycline + Tretinoin
Severity: Major
Omadacycline and Tretinoin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tetracyclines and systemic retinoids have been linked to intracranial hypertension (pseudotumor cerebri). Used together, the risk may be increased, with headache, visual disturbance and papilledema.
What this interaction means in plain words
Omadacycline and Tretinoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Omadacycline belongs to Anti Bacterial; Tretinoin belongs to Dermatology.
Why it happens
Possible additive effect on intracranial pressure; the mechanism is not well established.
What to do
Avoid combining oral tretinoin with tetracyclines where an alternative antibiotic exists. If combined, monitor for headache and visual changes and stop treatment if intracranial hypertension is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
- Tranexamic acid + Tretinoin Major
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
- Ampicillin-sulbactam + Omadacycline Moderate
Frequently asked questions
Can I take Omadacycline with Tretinoin?
MediHelp rates the interaction as major. Omadacycline and Tretinoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both tetracyclines and systemic retinoids have been linked to intracranial hypertension (pseudotumor cerebri). Used together, the risk may be increased, with headache, visual disturbance and papilledema.
How serious is the interaction between Omadacycline and Tretinoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining oral tretinoin with tetracyclines where an alternative antibiotic exists. If combined, monitor for headache and visual changes and stop treatment if intracranial hypertension is suspected.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Palovarotene. The full list is on the Tretinoin page.
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