Drug interactions
Dengue vaccine + Docetaxel
Severity: Major
Dengue vaccine and Docetaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel-induced immunosuppression may reduce the immune response to the dengue vaccine. The dengue vaccine is live attenuated, so there is also a risk of vaccine-related infection in immunocompromised patients.
What this interaction means in plain words
Dengue vaccine and Docetaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression impairs the vaccine response and permits replication of the live attenuated virus.
What to do
Avoid the live dengue vaccine during chemotherapy. Vaccinate before treatment starts or after immune recovery, as advised by the oncology team.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dengue vaccine and Docetaxel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Docetaxel
Frequently asked questions
Can I take Dengue vaccine with Docetaxel?
MediHelp rates the interaction as major. Dengue vaccine and Docetaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Docetaxel-induced immunosuppression may reduce the immune response to the dengue vaccine. The dengue vaccine is live attenuated, so there is also a risk of vaccine-related infection in immunocompromised patients.
How serious is the interaction between Dengue vaccine and Docetaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live dengue vaccine during chemotherapy. Vaccinate before treatment starts or after immune recovery, as advised by the oncology team.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
