Drug interactions
Dengue vaccine + Eribulin
Severity: Major
Dengue vaccine and Eribulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is live attenuated, and eribulin causes myelosuppression and immunosuppression. This may reduce the vaccine response and carries a risk of vaccine-strain infection.
What this interaction means in plain words
Dengue vaccine and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression impairs vaccine response and permits replication of live virus.
What to do
Avoid live vaccination during eribulin therapy. Defer until immune recovery, as advised by the oncology team.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Frequently asked questions
Can I take Dengue vaccine with Eribulin?
MediHelp rates the interaction as major. Dengue vaccine and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is live attenuated, and eribulin causes myelosuppression and immunosuppression. This may reduce the vaccine response and carries a risk of vaccine-strain infection.
How serious is the interaction between Dengue vaccine and Eribulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccination during eribulin therapy. Defer until immune recovery, as advised by the oncology team.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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