Drug interactions
Dengue vaccine + Fludrocortisone
Severity: Moderate
Dengue vaccine and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and corticosteroids at immunosuppressive doses can weaken the immune response and raise the risk of vaccine-related infection. Fludrocortisone at usual replacement doses has little immunosuppressive effect, so the concern applies mainly to higher cumulative corticosteroid exposure.
What this interaction means in plain words
Dengue vaccine and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-mediated immunosuppression may reduce the immune response to the vaccine and permit replication of the live attenuated virus.
What to do
At replacement doses, vaccination is generally acceptable; if the patient also takes immunosuppressive glucocorticoid doses, defer the live vaccine according to the vaccine labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dengue vaccine and Fludrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Dengue vaccine with Fludrocortisone?
MediHelp rates the interaction as moderate. Dengue vaccine and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dengue vaccine is a live attenuated vaccine, and corticosteroids at immunosuppressive doses can weaken the immune response and raise the risk of vaccine-related infection. Fludrocortisone at usual replacement doses has little immunosuppressive effect, so the concern applies mainly to higher cumulative corticosteroid exposure.
How serious is the interaction between Dengue vaccine and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: At replacement doses, vaccination is generally acceptable; if the patient also takes immunosuppressive glucocorticoid doses, defer the live vaccine according to the vaccine labeling.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
