Drug interactions
Dengue vaccine + Paclitaxel
Severity: Major
Dengue vaccine and Paclitaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel-induced immunosuppression may blunt the response to the dengue vaccine. As the vaccine is live attenuated, vaccination during chemotherapy also carries a risk of vaccine-related infection.
What this interaction means in plain words
Dengue vaccine and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immune response and permits replication of the live attenuated virus.
What to do
Avoid giving the live dengue vaccine during chemotherapy. Delay vaccination until immune recovery, as advised by the oncology team.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Dengue vaccine with Paclitaxel?
MediHelp rates the interaction as major. Dengue vaccine and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paclitaxel-induced immunosuppression may blunt the response to the dengue vaccine. As the vaccine is live attenuated, vaccination during chemotherapy also carries a risk of vaccine-related infection.
How serious is the interaction between Dengue vaccine and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live dengue vaccine during chemotherapy. Delay vaccination until immune recovery, as advised by the oncology team.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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