Drug interactions
Cyclosporin + Paclitaxel
Severity: Major
Cyclosporin and Paclitaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase paclitaxel exposure, increasing the risk of neutropenia, neuropathy and mucositis. The effect is relevant given paclitaxel's narrow therapeutic index.
What this interaction means in plain words
Cyclosporin and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Paclitaxel belongs to Oncology.
Why it happens
Cyclosporine inhibits P-glycoprotein and CYP3A4/2C8-mediated paclitaxel elimination.
What to do
Avoid unless planned; if combined, reduce the paclitaxel dose and monitor blood counts and neuropathy closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Cyclosporin with Paclitaxel?
MediHelp rates the interaction as major. Cyclosporin and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can increase paclitaxel exposure, increasing the risk of neutropenia, neuropathy and mucositis. The effect is relevant given paclitaxel's narrow therapeutic index.
How serious is the interaction between Cyclosporin and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless planned; if combined, reduce the paclitaxel dose and monitor blood counts and neuropathy closely.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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