Drug interactions
Dengue vaccine + Prednisolone
Severity: Major
Dengue vaccine and Prednisolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and immunosuppressive doses of corticosteroids may blunt the immune response and increase the risk of vaccine-related infection. Protection may therefore be inadequate.
What this interaction means in plain words
Dengue vaccine and Prednisolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Glucocorticoid immunosuppression reduces vaccine response and may permit uncontrolled replication of a live attenuated virus.
What to do
Avoid live vaccine in patients on immunosuppressive steroid doses; defer vaccination until steroids are stopped for the interval stated in the product labeling. Low-dose or short-course use may be assessed individually.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Prednisolone?
MediHelp rates the interaction as major. Dengue vaccine and Prednisolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and immunosuppressive doses of corticosteroids may blunt the immune response and increase the risk of vaccine-related infection. Protection may therefore be inadequate.
How serious is the interaction between Dengue vaccine and Prednisolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccine in patients on immunosuppressive steroid doses; defer vaccination until steroids are stopped for the interval stated in the product labeling. Low-dose or short-course use may be assessed individually.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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