Drug interactions
Dengue vaccine + Trastuzumab
Severity: Moderate
Dengue vaccine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine (Dengvaxia) is a live attenuated vaccine, and patients receiving cytotoxic or immunosuppressive cancer therapy may respond poorly to it and may be at risk of vaccine-related infection. Trastuzumab is usually given with chemotherapy, which is the main driver of this concern.
What this interaction means in plain words
Dengue vaccine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression from the oncology regimen can blunt the immune response to the vaccine and permit replication of a live attenuated virus.
What to do
Avoid live vaccines in patients receiving chemotherapy and defer vaccination until immune recovery. Vaccinate before starting treatment where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Dengue vaccine with Trastuzumab?
MediHelp rates the interaction as moderate. Dengue vaccine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dengue vaccine (Dengvaxia) is a live attenuated vaccine, and patients receiving cytotoxic or immunosuppressive cancer therapy may respond poorly to it and may be at risk of vaccine-related infection. Trastuzumab is usually given with chemotherapy, which is the main driver of this concern.
How serious is the interaction between Dengue vaccine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines in patients receiving chemotherapy and defer vaccination until immune recovery. Vaccinate before starting treatment where feasible.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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