Drug interactions
Desirudin + Fish oil
Severity: Moderate
Desirudin and Fish oil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids have mild antiplatelet effects and desirudin is a direct thrombin inhibitor. Combined use may modestly increase bleeding risk.
What this interaction means in plain words
Desirudin and Fish oil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis from platelet inhibition and direct thrombin inhibition.
What to do
Monitor for bleeding, including at injection sites, during desirudin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desirudin and Fish oil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fish oil
- Antithrombin alfa + Fish oil Moderate
- Antithrombin iii + Fish oil Moderate
- Aspirin / citric acid / sodium bicarbonate + Fish oil Moderate
- Aspirin + Fish oil Moderate
- Betrixaban + Fish oil Moderate
- Bivalirudin + Fish oil Moderate
Frequently asked questions
Can I take Desirudin with Fish oil?
MediHelp rates the interaction as moderate. Desirudin and Fish oil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omega-3 fatty acids have mild antiplatelet effects and desirudin is a direct thrombin inhibitor. Combined use may modestly increase bleeding risk.
How serious is the interaction between Desirudin and Fish oil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, including at injection sites, during desirudin therapy.
What other medicines interact with Fish oil?
MediHelp also lists interactions of Fish oil with, for example, Antithrombin alfa, Antithrombin iii, Aspirin / citric acid / sodium bicarbonate. The full list is on the Fish oil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
