Drug interactions
Desogestrel-ethinyl estradiol + Fexinidazole
Severity: Minor
Desogestrel-ethinyl estradiol and Fexinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and could modestly raise exposure to CYP3A4 substrates such as ethinyl estradiol and desogestrel's active metabolite. Clinical data for this pair are lacking.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Fexinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by fexinidazole reducing contraceptive steroid metabolism; not clinically established.
What to do
No dose change is needed; monitor for estrogenic adverse effects such as nausea or breast tenderness during the short fexinidazole course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Fexinidazole?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Fexinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexinidazole may inhibit CYP3A4 and could modestly raise exposure to CYP3A4 substrates such as ethinyl estradiol and desogestrel's active metabolite. Clinical data for this pair are lacking.
How serious is the interaction between Desogestrel-ethinyl estradiol and Fexinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for estrogenic adverse effects such as nausea or breast tenderness during the short fexinidazole course.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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