Drug interactions
Desogestrel-ethinyl estradiol + Lumefantrine
Severity: Minor
Desogestrel-ethinyl estradiol and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine may weakly induce CYP3A4, potentially lowering hormone concentrations. The clinical impact on contraceptive efficacy is uncertain and probably small.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction, increasing hormone metabolism.
What to do
No routine change is needed; counsel the patient about breakthrough bleeding and consider backup contraception if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Lumefantrine?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine may weakly induce CYP3A4, potentially lowering hormone concentrations. The clinical impact on contraceptive efficacy is uncertain and probably small.
How serious is the interaction between Desogestrel-ethinyl estradiol and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient about breakthrough bleeding and consider backup contraception if it occurs.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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