Drug interactions
Desogestrel-ethinyl estradiol + Mobocertinib
Severity: Major
Desogestrel-ethinyl estradiol and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib is a CYP3A inducer and may reduce hormonal contraceptive exposure. This may lead to breakthrough bleeding and contraceptive failure.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 induction by mobocertinib increases clearance of the contraceptive steroids.
What to do
Advise effective non-hormonal contraception during treatment and for the period recommended in the labeling afterward.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Mobocertinib?
MediHelp rates the interaction as major. Desogestrel-ethinyl estradiol and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib is a CYP3A inducer and may reduce hormonal contraceptive exposure. This may lead to breakthrough bleeding and contraceptive failure.
How serious is the interaction between Desogestrel-ethinyl estradiol and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise effective non-hormonal contraception during treatment and for the period recommended in the labeling afterward.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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