Drug interactions
Desogestrel-ethinyl estradiol + Nefazodone
Severity: Minor
Desogestrel-ethinyl estradiol and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits CYP3A4, which contributes to the metabolism of ethinyl estradiol, so estrogen exposure may rise modestly. The clinical consequence is usually small, though estrogen-related adverse effects such as nausea, breast tenderness or headache could become more noticeable.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nefazodone inhibits intestinal and hepatic CYP3A4, reducing the first-pass and systemic clearance of ethinyl estradiol.
What to do
No routine change is needed; ask the patient about estrogenic adverse effects and review the contraceptive dose if these become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Nefazodone?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone inhibits CYP3A4, which contributes to the metabolism of ethinyl estradiol, so estrogen exposure may rise modestly. The clinical consequence is usually small, though estrogen-related adverse effects such as nausea, breast tenderness or headache could become more noticeable.
How serious is the interaction between Desogestrel-ethinyl estradiol and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; ask the patient about estrogenic adverse effects and review the contraceptive dose if these become troublesome.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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