Drug interactions
Desogestrel-ethinyl estradiol + Neomycin po
Severity: Minor
Desogestrel-ethinyl estradiol and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin has been theorized to reduce enterohepatic recycling of ethinyl estradiol by altering gut flora. Documented contraceptive failure is rare.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced gut bacterial deconjugation of estrogen conjugates may lower ethinyl estradiol reabsorption.
What to do
No routine additional contraception is needed. Counsel patients to report vomiting, diarrhea or breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Neomycin po?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin has been theorized to reduce enterohepatic recycling of ethinyl estradiol by altering gut flora. Documented contraceptive failure is rare.
How serious is the interaction between Desogestrel-ethinyl estradiol and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine additional contraception is needed. Counsel patients to report vomiting, diarrhea or breakthrough bleeding.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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