Drug interactions
Desogestrel-ethinyl estradiol + Olanzapine
Severity: Minor
Desogestrel-ethinyl estradiol and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP1A2 inhibitor and may modestly raise olanzapine exposure. Increased sedation or other olanzapine adverse effects may occur in some patients.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP1A2-mediated olanzapine metabolism by ethinyl estradiol.
What to do
Monitor for sedation and anticholinergic or metabolic effects when starting or stopping the contraceptive, and adjust the olanzapine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Olanzapine?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP1A2 inhibitor and may modestly raise olanzapine exposure. Increased sedation or other olanzapine adverse effects may occur in some patients.
How serious is the interaction between Desogestrel-ethinyl estradiol and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic or metabolic effects when starting or stopping the contraceptive, and adjust the olanzapine dose if needed.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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