Drug interactions
Desogestrel-ethinyl estradiol + Penicillin g aqueous
Severity: Minor
Desogestrel-ethinyl estradiol and Penicillin g aqueous: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins have been theorized to reduce contraceptive efficacy, but controlled data show no meaningful decrease in hormone levels. Parenteral penicillin G has little effect on gut flora recycling.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed disruption of enterohepatic estrogen recycling; not well established.
What to do
No additional contraceptive measures are generally needed. Advise backup contraception only if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Penicillin g aqueous?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins have been theorized to reduce contraceptive efficacy, but controlled data show no meaningful decrease in hormone levels. Parenteral penicillin G has little effect on gut flora recycling.
How serious is the interaction between Desogestrel-ethinyl estradiol and Penicillin g aqueous?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraceptive measures are generally needed. Advise backup contraception only if vomiting or severe diarrhea occurs.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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