Drug interactions
Desogestrel-ethinyl estradiol + Selegiline transdermal
Severity: Minor
Desogestrel-ethinyl estradiol and Selegiline transdermal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives increase selegiline exposure, which with oral dosing is substantial. With the transdermal route, the increase is less relevant but may enhance MAO-related effects such as blood pressure changes.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Selegiline transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ethinyl estradiol inhibits hepatic metabolism of selegiline, reducing its clearance.
What to do
Monitor blood pressure and adverse effects, and adjust selegiline dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Selegiline transdermal?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Selegiline transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptives increase selegiline exposure, which with oral dosing is substantial. With the transdermal route, the increase is less relevant but may enhance MAO-related effects such as blood pressure changes.
How serious is the interaction between Desogestrel-ethinyl estradiol and Selegiline transdermal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adverse effects, and adjust selegiline dose if needed.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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