Drug interactions
Desogestrel-ethinyl estradiol + Sulfadiazine
Severity: Minor
Desogestrel-ethinyl estradiol and Sulfadiazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
It has been proposed that antibacterials reduce enterohepatic recycling of ethinyl estradiol by altering gut flora. Pharmacokinetic studies with non-rifamycin antibiotics generally show no consistent reduction in hormone levels or ovulation suppression. Any risk of contraceptive failure is considered low.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in gut bacterial hydrolysis of estrogen conjugates, lowering enterohepatic recirculation of ethinyl estradiol.
What to do
No routine change is required. Advise the patient to use backup contraception if vomiting or severe diarrhea occurs during the illness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Sulfadiazine?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. It has been proposed that antibacterials reduce enterohepatic recycling of ethinyl estradiol by altering gut flora. Pharmacokinetic studies with non-rifamycin antibiotics generally show no consistent reduction in hormone levels or ovulation suppression. Any risk of contraceptive failure is considered low.
How serious is the interaction between Desogestrel-ethinyl estradiol and Sulfadiazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required. Advise the patient to use backup contraception if vomiting or severe diarrhea occurs during the illness.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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