Drug interactions
Desogestrel-ethinyl estradiol + Triazolam
Severity: Moderate
Desogestrel-ethinyl estradiol and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol can inhibit CYP3A4 to a small degree, which may raise triazolam concentrations. This could increase sedation, psychomotor impairment and next-day drowsiness.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethinyl estradiol weakly inhibits CYP3A4-mediated oxidative metabolism of triazolam.
What to do
Monitor for excessive sedation and consider using the lowest effective triazolam dose. Reduce the dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Triazolam?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinyl estradiol can inhibit CYP3A4 to a small degree, which may raise triazolam concentrations. This could increase sedation, psychomotor impairment and next-day drowsiness.
How serious is the interaction between Desogestrel-ethinyl estradiol and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider using the lowest effective triazolam dose. Reduce the dose if oversedation occurs.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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