Drug interactions
Desvenlafaxine + Dextroamphetamine transdermal
Severity: Major
Desvenlafaxine and Dextroamphetamine transdermal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines enhance release of monoamines and combined with serotonergic antidepressants may precipitate serotonin syndrome. Both agents can also raise blood pressure and heart rate.
What this interaction means in plain words
Desvenlafaxine and Dextroamphetamine transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic and noradrenergic effects from monoamine release by amphetamine and reuptake inhibition by desvenlafaxine.
What to do
Start at low doses and increase gradually while monitoring for agitation, tremor, hyperthermia, diarrhea and autonomic instability. Stop the amphetamine and serotonergic drug if serotonin syndrome develops; monitor blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Dextroamphetamine transdermal?
MediHelp rates the interaction as major. Desvenlafaxine and Dextroamphetamine transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphetamines enhance release of monoamines and combined with serotonergic antidepressants may precipitate serotonin syndrome. Both agents can also raise blood pressure and heart rate.
How serious is the interaction between Desvenlafaxine and Dextroamphetamine transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at low doses and increase gradually while monitoring for agitation, tremor, hyperthermia, diarrhea and autonomic instability. Stop the amphetamine and serotonergic drug if serotonin syndrome develops; monitor blood pressure.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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