Drug interactions
Desvenlafaxine + Doxorubicin
Severity: Minor
Desvenlafaxine and Doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is a CYP2D6 substrate in part, and desvenlafaxine's weak inhibition of this enzyme is unlikely to change exposure meaningfully. A clinically important effect is not established.
What this interaction means in plain words
Desvenlafaxine and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Doxorubicin belongs to Oncology.
Why it happens
Theoretical weak CYP2D6 inhibition; doxorubicin clearance depends on several pathways.
What to do
No dose adjustment is needed; continue standard monitoring of cardiac function and blood counts during doxorubicin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Doxorubicin
Frequently asked questions
Can I take Desvenlafaxine with Doxorubicin?
MediHelp rates the interaction as minor. Desvenlafaxine and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is a CYP2D6 substrate in part, and desvenlafaxine's weak inhibition of this enzyme is unlikely to change exposure meaningfully. A clinically important effect is not established.
How serious is the interaction between Desvenlafaxine and Doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; continue standard monitoring of cardiac function and blood counts during doxorubicin therapy.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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