Drug interactions
Desvenlafaxine + Indinavir
Severity: Minor
Desvenlafaxine and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, a minor elimination route for desvenlafaxine, so levels may rise slightly. Clinically important toxicity is unlikely in most patients.
What this interaction means in plain words
Desvenlafaxine and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition reduces minor oxidative metabolism of desvenlafaxine.
What to do
No routine dose change is required. Monitor for nausea, dizziness and raised blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Indinavir?
MediHelp rates the interaction as minor. Desvenlafaxine and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4, a minor elimination route for desvenlafaxine, so levels may rise slightly. Clinically important toxicity is unlikely in most patients.
How serious is the interaction between Desvenlafaxine and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor for nausea, dizziness and raised blood pressure.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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