Drug interactions
Desvenlafaxine + Isoniazid
Severity: Moderate
Desvenlafaxine and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak monoamine oxidase inhibiting activity, and desvenlafaxine increases serotonin. Together they could theoretically cause serotonin syndrome, although reports are rare.
What this interaction means in plain words
Desvenlafaxine and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak MAO inhibition by isoniazid combined with serotonin-norepinephrine reuptake inhibition.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability, particularly at initiation or dose increases. Stop either drug if serotonin toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desvenlafaxine and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Isoniazid?
MediHelp rates the interaction as moderate. Desvenlafaxine and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid has weak monoamine oxidase inhibiting activity, and desvenlafaxine increases serotonin. Together they could theoretically cause serotonin syndrome, although reports are rare.
How serious is the interaction between Desvenlafaxine and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability, particularly at initiation or dose increases. Stop either drug if serotonin toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
